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Anti-Human COMMD5 Polyclonal Antibody (HP513014)

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Overview
Catalog No.HP513014
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human COMMD5 (Glu32-Asp224).
Target COMM domain-containing protein 5, Hypertension-related calcium-regulated gene protein, HCaRG, COMMD5
Purification Purified by antigen affinity column.
Accession Q9GZQ3
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

COMM domain-containing protein 5 (COMMD5) is a ~24 kDa protein. Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis.

1. Healy, MD. et al. (2023) Cell 186, 2219-2237.e29. PMID: 37172566
2. Laulumaa, S. et al. (2024) Nature structural & molecular biology 31, 925-938. PMID: 38459129
3. Mao, X. et al. (2011) The Journal of biological chemistry 286, 32355-65. PMID: 21778237
4. Burstein, E. et al. (2005) The Journal of biological chemistry 280, 22222-32. PMID: 15799966
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human COMMD5 Polyclonal Antibody

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