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Anti-Human COX17 Polyclonal Antibody (HC587014)

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Overview
Catalog No.HC587014
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human COX17 (Lys21-Ile63).
Target Cytochrome c oxidase copper chaperone, COX17
Purification Purified by antigen affinity column.
Accession Q14061
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Cytochrome c oxidase copper chaperone (COX17) is a ~6 kDa protein. Copper metallochaperone involved in the assembly of cytochrome c oxidase (respiratory chain complex IV, CIV). Binds two copper ions and delivers them to metallochaperones SCO1 and SCO2, which co-chaperone the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2), and to metallochaperone COX11 which relays the copper to the Cu(B) site on the cytochrome c oxidase subunit I (MT-CO1/COX1).

1. Leary, SC. et al. (2004) Human molecular genetics 13, 1839-48. PMID: 15229189
2. Oswald, C. et al. (2009) Journal of molecular biology 389, 470-9. PMID: 19393246
3. Vanišová, M. et al. (2019) Folia biologica 65, 181-187. PMID: 31903891
4. Nývltová, E. et al. (2022) Nature communications 13, 3615. PMID: 35750769
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human COX17 Polyclonal Antibody

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