Anti-Human CRCP Polyclonal Antibody (HF859014)

Name: Anti-Human CRCP Polyclonal Antibody
Brand: abinScience
SKU: HF859014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HF859014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CRCP (Ser12-Ala148).

Target

CGRPRCP, HsC17, Calcitonin gene-related peptide-receptor component protein, CGRP-RCP, CRCP, RNA polymerase III subunit C9, DNA-directed RNA polymerase III subunit RPC9, CGRP-receptor component protein

Purification

Purified by antigen affinity column.

Accession

O75575

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

DNA-directed RNA polymerase III subunit RPC9 (CRCP) is a ~16 kDa protein. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response.

1. Canella, D. et al. (2010) Genome research 20, 710-21. PMID: 20413673

2. Girbig, M. et al. (2021) Nature structural & molecular biology 28, 210-219. PMID: 33558764

3. Hou, H. et al. (2021) Nature communications 12, 6135. PMID: 34675218

4. Wang, Q. et al. (2021) Nature structural & molecular biology 28, 220-227. PMID: 33558766

5. Ablasser, A. et al. (2009) Nature immunology 10, 1065-72. PMID: 19609254

6. Chiu, YH. et al. (2009) Cell 138, 576-91. PMID: 19631370

Note

For research use only.

Images

References

Datasheet

Anti-Human CRCP Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human CRCP Polyclonal Antibody (HF859014)

Overview

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References

Datasheet

SDS

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