

| Catalog No. | HW591014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human CRHR1 (Ser24-Lys113). | ||||||||
| Target | CRH-R1, CRHR1, CRFR, CRFR-1, Corticotropin-releasing factor receptor 1, CRFR1, CRF-R1, CRF-R-1, Corticotropin-releasing hormone receptor 1, CRHR, CRH-R-1 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | P34998 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Corticotropin-releasing factor receptor 1 (CRHR1) is a ~47 kDa protein. G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. | ||||||||
| Note | For research use only. |
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