Anti-Human CSNK2A1/CK2A1 Polyclonal Antibody (HX027014)

Name: Anti-Human CSNK2A1/CK2A1 Polyclonal Antibody
Brand: abinScience
SKU: HX027014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HX027014

Description

Anti-Human CSNK2A1/CK2A1 Polyclonal Antibody (HX027014) is a rabbit polyclonal antibody detecting CSNK2A1 in ELISA, WB. Suitable for Mouse, Bovine, Chicken, Human, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CSNK2A1/CK2A1 (Asp14-Ser337).

Target

CSNK2A1, CK II alpha, CK2A1, Casein kinase II subunit alpha

Purification

Purified by antigen affinity column.

Accession

P68400, Q60737, Q8NEV1, P19139, P19784, O54833

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Casein kinase II subunit alpha (CSNK2A1/CK2A1) is a ~45 kDa protein. Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation.

1. Keller, DM. et al. (2001) Molecular cell 7, 283-92. PMID: 11239457

2. Sayed, M. et al. (2001) Oncogene 20, 6994-7005. PMID: 11704824

3. Shin, S. et al. (2005) The EMBO journal 24, 3532-42. PMID: 16193064

4. Melander, F. et al. (2008) The Journal of cell biology 181, 213-26. PMID: 18411307

5. Chapman, JR. et al. (2008) EMBO reports 9, 795-801. PMID: 18583988

6. Wu, L. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 11200-5. PMID: 18678890

7. St-Denis, NA. et al. (2009) Molecular and cellular biology 29, 2068-81. PMID: 19188443

8. Takeishi, Y. et al. (2010) Genes to cells : devoted to molecular & cellular mechanisms 15, 761-71. PMID: 20545769

9. Hung, MS. et al. (2010) PloS one 5, e11418. PMID: 20625391

10. Matsumoto, G. et al. (2011) Molecular cell 44, 279-89. PMID: 22017874

Note

For research use only.

Images

References

Datasheet

Anti-Human CSNK2A1/CK2A1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human CSNK2A1/CK2A1 Polyclonal Antibody (HX027014)

Overview

Images

References

Datasheet

SDS

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