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Anti-Human CTNND1 Polyclonal Antibody (HT249014)

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Overview
Catalog No.HT249014
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human CTNND1 (Glu367-Gln601).
Target CTNND1, p120 catenin, Cadherin-associated Src substrate, CAS, Catenin delta-1, p120(ctn), KIAA0384, p120(cas)
Purification Purified by antigen affinity column.
Accession O60716
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Catenin delta-1 (CTNND1) is a ~108 kDa protein. Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.

1. Davis, MA. et al. (2003) The Journal of cell biology 163, 525-34. PMID: 14610055
2. Ishiyama, N. et al. (2010) Cell 141, 117-28. PMID: 20371349
3. Kanno, M. et al. (2008) Experimental cell research 314, 1683-92. PMID: 18343367
4. Daniel, JM. et al. (1999) Molecular and cellular biology 19, 3614-23. PMID: 10207085
5. Hosking, CR. et al. (2007) Molecular biology of the cell 18, 1918-27. PMID: 17344476
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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V₁ (Stock Vol.)
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C₂ (Working Conc.)
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Anti-Human CTNND1 Polyclonal Antibody

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