Anti-Human CXADR Recombinant Antibody (SAA0357) (HX017013)

Name: Anti-Human CXADR Recombinant Antibody (SAA0357)
Brand: abinScience
SKU: HX017013
Price: 126 USD
Availability: InStock

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Overview

Catalog No.	HX017013
Description	Anti-Human CXADR Recombinant Antibody (SAA0357) (HX017013) is a mouse monoclonal antibody detecting CXADR in Blocking, FCM, IHC. Suitable for Human. Highlights ●Affinity Purified — Minimal background and high purity for reliable results. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	Blocking, FCM, IHC
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG2a, kappa
Clone ID	SAA0357
Target	Coxsackievirus and adenovirus receptor, CAR, hCAR, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, HCVADR, CXADR, CAR
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P78310
RRID	Anti-Human CXADR Antibody (SAA0357) (abinScience Cat# HX017013, RRID:AB_3725894)
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Coxsackievirus and adenovirus receptor (CXADR) is a ~40 kDa protein. Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
Note	For research use only.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

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Flow Cytometry

Flow-cytometry using anti-human CXADR antibody.HT-29 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CXADR antibody monoclonal antibody (Catalog # HX017013 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.
Flow Cytometry

Flow-cytometry using anti-human CXADR antibody.NCI-H460 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CXADR antibody monoclonal antibody (Catalog # HX017013 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.
SDS-PAGE

SDS-PAGE for Anti-Human CXADR Antibody (SAA0357).
Flow CytoMetry

Flow-cytometry using PE anti-human CXADR antibody. HT-29 cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CXADR monoclonal antibody (Catalog: HX017013, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.

References

Datasheet

Anti-Human CXADR Recombinant Antibody (SAA0357).pdf

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Anti-Human CXADR Recombinant Antibody (SAA0357) (HX017013)

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