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Anti-Human CYLD Polyclonal Antibody (HV742014)

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Overview
Catalog No.HV742014
Description
Anti-Human CYLD Polyclonal Antibody (HV742014) is a rabbit polyclonal antibody detecting CYLD. Suitable for Rat, Human, and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human CYLD (Asn553-Lys956).
Target CYLD, CYLD1, Deubiquitinating enzyme CYLD, EC:3.4.19.12, KIAA0849, Ubiquitin carboxyl-terminal hydrolase CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9NQC7
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Ubiquitin carboxyl-terminal hydrolase CYLD is a ~107 kDa protein. Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-induced necroptosis. Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules.

1. Komander, D. et al. (2008) Molecular cell 29, 451-64. PMID: 18313383
2. Friedman, CS. et al. (2008) EMBO reports 9, 930-6. PMID: 18636086
3. Draber, P. et al. (2015) Cell reports 13, 2258-72. PMID: 26670046
4. Hrdinka, M. et al. (2016) Cell reports 14, 2846-58. PMID: 26997266
5. Schlicher, L. et al. (2016) EMBO reports 17, 1485-1497. PMID: 27458237
6. Elliott, PR. et al. (2016) Molecular cell 63, 990-1005. PMID: 27591049
7. Ohtake, F. et al. (2016) Molecular cell 64, 251-266. PMID: 27746020
8. Ji, YX. et al. (2018) Nature medicine 24, 213-223. PMID: 29291351
9. Dobson-Stone, C. et al. (2020) Brain : a journal of neurology 143, 783-799. PMID: 32185393
10. Trompouki, E. et al. (2003) Nature 424, 793-6. PMID: 12917689
Note For research use only
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Datasheet
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Formula
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Anti-Human CYLD Polyclonal Antibody

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