

| Catalog No. | HT416014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human DCX (Arg178-Gly276). | ||||||||
| Target | Lis-X, LISX, DCX, Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, DBCN | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | O43602 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Neuronal migration protein doublecortin (DCX) is a ~40 kDa protein. Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-Human DCX polyclonal antibody at 1ug/mL on recombinant Human DCX (Catalog No. HT416012).




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