Anti-Human DDX46 Polyclonal Antibody (HD537014)

Name: Anti-Human DDX46 Polyclonal Antibody
Brand: abinScience
SKU: HD537014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HD537014

Description

Anti-Human DDX46 Polyclonal Antibody (HD537014) is a rabbit polyclonal antibody detecting DDX46. Suitable for Rat, Human, and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human DDX46 (Asp322-Lys765).

Target

DDX46, DEAD box protein 46, EC:3.6.4.13, KIAA0801, PRP5 homolog, Probable ATP-dependent RNA helicase DDX46

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q7L014

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Probable ATP-dependent RNA helicase DDX46 is a ~117 kDa protein. Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site.

1. Will, CL. et al. (2002) The EMBO journal 21, 4978-88. PMID: 12234937

2. Zhang, Z. et al. (2020) Nature 583, 310-313. PMID: 32494006

3. Tholen, J. et al. (2022) Science (New York, N.Y.) 375, 50-57. PMID: 34822310

4. Yang, F. et al. (2023) Nature communications 14, 897. PMID: 36797247

Note

For research use only

Images

References

Datasheet

Anti-Human DDX46 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human DDX46 Polyclonal Antibody (HD537014)

Overview

Images

References

Datasheet

SDS

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