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Anti-Human DHX58 Polyclonal Antibody (HC201014)

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Overview
Catalog No.HC201014
Description
Anti-Human DHX58 Polyclonal Antibody (HC201014) is a rabbit polyclonal antibody detecting DHX58. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human DHX58 (Met1-Asp678).
Target ATP-dependent RNA helicase DHX58, ATP-dependent helicase LGP2, D11LGP2E, DHX58, EC:3.6.4.13, LGP2, Protein D11Lgp2 homolog, RIG-I-like receptor 3, RIG-I-like receptor LGP2, RLR, RLR-3
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q96C10
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

ATP-dependent RNA helicase DHX58 is a ~76 kDa protein. Acts as a regulator of RIGI and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to RIGI and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on RIG-I signaling may involve the following mechanisms: competition with RIGI for binding to the viral RNA, binding to RIGI and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by RIGI and IFIH1/MDA5.

1. Paine, I. et al. (2019) American journal of human genetics 105, 302-316. PMID: 31256877
Note For research use only
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Formula
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Anti-Human DHX58 Polyclonal Antibody

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