Anti-Human DNAJB2 Polyclonal Antibody (HB700014)

Name: Anti-Human DNAJB2 Polyclonal Antibody
Brand: abinScience
SKU: HB700014
Price: 96 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HB700014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human DNAJB2 (Ala2-Gly91).

Target

HSJ-1, Heat shock protein J1, DNAJB2, Heat shock 40 kDa protein 3, DnaJ homolog subfamily B member 2, HSPF3, HSJ1

Purification

Purified by antigen affinity column.

Accession

P25686

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

DnaJ homolog subfamily B member 2 (DNAJB2) is a ~35 kDa protein. Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins.

1. Gao, XC. et al. (2012) The Journal of biological chemistry 287, 6044-52. PMID: 22219199

2. Cheetham, ME. et al. (1994) European journal of biochemistry 226, 99-107. PMID: 7957263

3. Westhoff, B. et al. (2005) Current biology : CB 15, 1058-64. PMID: 15936278

4. Gao, XC. et al. (2011) PloS one 6, e19763. PMID: 21625540

5. Chapple, JP. et al. (2003) The Journal of biological chemistry 278, 19087-94. PMID: 12754272

6. Rose, JM. et al. (2011) Human molecular genetics 20, 16-27. PMID: 20889486

7. Meimaridou, E. et al. (2011) Molecular endocrinology (Baltimore, Md.) 25, 1650-60. PMID: 21719532

8. Labbadia, J. et al. (2012) Brain : a journal of neurology 135, 1180-96. PMID: 22396390

9. Novoselov, SS. et al. (2013) PloS one 8, e73944. PMID: 24023695

Note

For research use only.

Images

References

Datasheet

Anti-Human DNAJB2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human DNAJB2 Polyclonal Antibody (HB700014)

Overview

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References

Datasheet

SDS

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