Anti-Human DNAJB6 Polyclonal Antibody (HF866014)

Name: Anti-Human DNAJB6 Polyclonal Antibody
Brand: abinScience
SKU: HF866014
Price: 96 USD
Availability: InStock

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20ug
50ug
100ug

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Datasheet
SDS

Overview

Catalog No.

HF866014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human DNAJB6 (Met1-Gly124).

Target

HHDJ1, Heat shock protein J2, MRJ, HSJ-2, HSJ2, MSJ-1, DnaJ homolog subfamily B member 6, DNAJB6, MSJ1

Purification

Purified by antigen affinity column.

Accession

O75190

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

DnaJ homolog subfamily B member 6 (DNAJB6) is a ~36 kDa protein. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity.

1. Izawa, I. et al. (2000) The Journal of biological chemistry 275, 34521-7. PMID: 10954706

2. Tsai, PC. et al. (2017) Clinical genetics 92, 150-157. PMID: 28233300

3. Chuang, JZ. et al. (2002) The Journal of biological chemistry 277, 19831-8. PMID: 11896048

4. Sarparanta, J. et al. (2012) Nature genetics 44, 450-5, S1-2. PMID: 22366786

5. Hageman, J. et al. (2010) Molecular cell 37, 355-69. PMID: 20159555

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-DNAJB6 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate

References

Datasheet

Anti-Human DNAJB6 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human DNAJB6 Polyclonal Antibody (HF866014)

Overview

Images

References

Datasheet

SDS

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