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Anti-Human DYNLL1 Polyclonal Antibody (HX228014)

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Overview
Catalog No.HX228014
Description
Anti-Human DYNLL1 Polyclonal Antibody (HX228014) is a rabbit polyclonal antibody detecting DYNLL1 in ELISA, IHC, WB. Suitable for Bovine, Human, Macaca fascicularis, Mouse, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human DYNLL1 (Cys2-Gly89).
Target DNCL1, Dynein light chain 1, cytoplasmic, DNCLC1, 8 kDa dynein light chain, DLC1, HDLC1, PIN, Dynein light chain LC8-type 1, DLC8, Protein inhibitor of neuronal nitric oxide synthase, DYNLL1
Purification Purified by antigen affinity column.
Accession P63167
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Dynein light chain 1, cytoplasmic (DYNLL1) is a ~10 kDa protein. Component of dynein, a family of motor proteins essential for movement along microtubules. Required for structural and functional integrity of cilia. Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.

1. Puthalakath, H. et al. (1999) Molecular cell 3, 287-96. PMID: 10198631
2. Vadlamudi, RK. et al. (2004) Cancer cell 5, 575-85. PMID: 15193260
3. Rayala, SK. et al. (2005) EMBO reports 6, 538-44. PMID: 15891768
4. Rayala, SK. et al. (2006) The Journal of biological chemistry 281, 19092-9. PMID: 16684779
5. He, YJ. et al. (2018) Nature 563, 522-526. PMID: 30464262
6. Swift, ML. et al. (2023) Nature structural & molecular biology 30, 1456-1467. PMID: 37696958
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human DYNLL1 Polyclonal Antibody

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