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Anti-Human EIF4E2 Polyclonal Antibody (HT124014)

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Overview
Catalog No.HT124014
Description
Anti-Human EIF4E2 Polyclonal Antibody (HT124014) is a rabbit polyclonal antibody detecting EIF4E2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human EIF4E2 (Glu53-Pro245).
Target Eukaryotic translation initiation factor 4E type 2, eIF-4E type 2, eIF4E type 2, Eukaryotic translation initiation factor 4E homologous protein, Eukaryotic translation initiation factor 4E-like 3, eIF4E-like protein 4E-LP, mRNA cap-binding protein 4EHP, h4EHP, mRNA cap-binding protein type 3, EIF4E2, EIF4EL3
Purification Purified by antigen affinity column.
Accession O60573
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Eukaryotic translation initiation factor 4E type 2 (EIF4E2) is a ~28 kDa protein. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. In P-bodies, component of a complex that promotes miRNA-mediated translational repression. Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism.

1. Rosettani, P. et al. (2007) Journal of molecular biology 368, 691-705. PMID: 17368478
2. Morita, M. et al. (2012) Molecular and cellular biology 32, 3585-93. PMID: 22751931
3. von Stechow, L. et al. (2015) Molecular and cellular biology 35, 1254-68. PMID: 25624349
4. Zhang, X. et al. (2021) Molecular cell 81, 1187-1199.e5. PMID: 33581076
5. Rom, E. et al. (1998) The Journal of biological chemistry 273, 13104-9. PMID: 9582349
6. Chapat, C. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 5425-5430. PMID: 28487484
Note For research use only.
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Datasheet
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Formula
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Anti-Human EIF4E2 Polyclonal Antibody

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