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Anti-Human ERLIN2 Polyclonal Antibody (HF861014)

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Overview
Catalog No.HF861014
Description
Anti-Human ERLIN2 Polyclonal Antibody (HF861014) is a rabbit polyclonal antibody detecting ERLIN2. Suitable for Rat, Mouse, and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human ERLIN2 (Pro47-Asn339).
Target C8orf2, ERLIN2, Endoplasmic reticulum lipid raft-associated protein 2, Erlin-2, SPFH domain-containing protein 2, SPFH2, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession O94905
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Erlin-2 (ERLIN2) is a ~37 kDa protein. Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex.

1. Pearce, MM. et al. (2007) The Journal of biological chemistry 282, 20104-15. PMID: 17502376
2. Pearce, MM. et al. (2009) The Journal of biological chemistry 284, 10433-45. PMID: 19240031
3. Jo, Y. et al. (2011) The Journal of biological chemistry 286, 15022-31. PMID: 21343306
4. Huber, MD. et al. (2013) The Journal of cell biology 203, 427-36. PMID: 24217618
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human ERLIN2 Polyclonal Antibody

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