Anti-Human FA2H Polyclonal Antibody (HP606014)

Name: Anti-Human FA2H Polyclonal Antibody
Brand: abinScience
SKU: HP606014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HP606014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human FA2H (Ser12-Arg86).

Target

Fatty acid 2-hydroxylase, Fatty acid alpha-hydroxylase, FAXDC1, FAAH, FA2H, Fatty acid hydroxylase domain-containing protein 1

Purification

Purified by antigen affinity column.

Accession

Q7L5A8

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Fatty acid 2-hydroxylase (FA2H) is a ~42 kDa protein. Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis.

1. Alderson, NL. et al. (2004) The Journal of biological chemistry 279, 48562-8. PMID: 15337768

2. Alderson, NL. et al. (2005) Journal of lipid research 46, 1569-75. PMID: 15863841

3. Uchida, Y. et al. (2007) The Journal of biological chemistry 282, 13211-9. PMID: 17355976

4. Guo, L. et al. (2012) Journal of lipid research 53, 1327-35. PMID: 22517924

Note

For research use only.

Images

References

Datasheet

Anti-Human FA2H Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human FA2H Polyclonal Antibody (HP606014)

Overview

Images

References

Datasheet

SDS

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