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Anti-Human FANCM Polyclonal Antibody (HA265014)

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Overview
Catalog No.HA265014
Description
Anti-Human FANCM Polyclonal Antibody (HA265014) is a rabbit polyclonal antibody detecting FANCM in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human FANCM (Ser281-His620).
Target Fanconi anemia group M protein, Protein FACM, 3.6.4.13, ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef ortholog, FANCM, KIAA1596
Purification Purified by antigen affinity column.
Accession Q8IYD8
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Fanconi anemia group M protein (FANCM) is a ~232 kDa protein. DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX.

1. Meetei, AR. et al. (2005) Nature genetics 37, 958-63. PMID: 16116422
2. Singh, TR. et al. (2009) Blood 114, 174-80. PMID: 19423727
3. Yan, Z. et al. (2010) Molecular cell 37, 865-78. PMID: 20347428
4. Singh, TR. et al. (2010) Molecular cell 37, 879-86. PMID: 20347429
5. Fouquet, B. et al. (2017) eLife 6. PMID: 29231814
6. Ciccia, A. et al. (2007) Molecular cell 25, 331-43. PMID: 17289582
Note For research use only.
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Datasheet
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Formula
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Anti-Human FANCM Polyclonal Antibody

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