Anti-Human FBXO22 Polyclonal Antibody (HP533014)

Name: Anti-Human FBXO22 Polyclonal Antibody
Brand: abinScience
SKU: HP533014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HP533014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human FBXO22 (Arg61-Lys403).

Target

FBX22, F-box protein FBX22p44, FBXO22, F-box only protein 22

Purification

Purified by antigen affinity column.

Accession

Q8NEZ5

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

F-box only protein 22 (FBXO22) is a ~44 kDa protein. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that is implicated in the control of various cellular processes such as cell cycle control, transcriptional regulation, DNA damage repair, and apoptosis. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Acts as a key regulator of histone methylation marks namely H3K9 and H3K36 methylation through the regulation of histone demethylase KDM4A protein levels. In complex with KDM4A, also regulates the abundance of TP53 by targeting methylated TP53 for degradation at the late senescent stage. Under oxidative stress, promotes the ubiquitination and degradation of BACH1.

1. Tan, MK. et al. (2011) Molecular and cellular biology 31, 3687-99. PMID: 21768309

2. Johmura, Y. et al. (2016) Nature communications 7, 10574. PMID: 26868148

3. Cao, S. et al. (2024) Cell 187, 7568-7584.e22. PMID: 39504958

4. Ge, MK. et al. (2023) Cell metabolism 35, 2216-2230.e8. PMID: 37979583

5. Zhou, Y. et al. (2024) Journal of medical virology 96, e29891. PMID: 39223933

Note

For research use only.

Images

References

Datasheet

Anti-Human FBXO22 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human FBXO22 Polyclonal Antibody (HP533014)

Overview

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References

Datasheet

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