

| Catalog No. | HC276014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human FHL2 (Gly16-Ser98). | ||||||||
| Target | DRAL, FHL2, LIM domain protein DRAL, FHL-2, Skeletal muscle LIM-protein 3, Four and a half LIM domains protein 2, SLIM-3, SLIM3 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q14192 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Four and a half LIM domains protein 2 (FHL2) is a ~32 kDa protein. May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. 1. Dierck, F. et al. (2017) The Journal of biological chemistry 292, 15180-15191. PMID: 28717008 | ||||||||
| Note | For research use only. |
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