Anti-Human FMO5 Polyclonal Antibody (HD536014)

Name: Anti-Human FMO5 Polyclonal Antibody
Brand: abinScience
SKU: HD536014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HD536014

Description

Anti-Human FMO5 Polyclonal Antibody (HD536014) is a rabbit polyclonal antibody detecting FMO5. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human FMO5 (Met1-Ser512).

Target

Baeyer-Villiger monooxygenase 1, Dimethylaniline monooxygenase [N-oxide-forming] 5, Dimethylaniline oxidase 5, EC:1.14.13.-, EC:1.14.13.8, EC:1.6.3.1, FMO 5, FMO5, Flavin-containing monooxygenase 5, NADPH oxidase, hBVMO1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P49326

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Flavin-containing monooxygenase 5 (FMO5) is a ~60 kDa protein. Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline.

1. Lai, WG. et al. (2011) Drug metabolism and disposition: the biological fate of chemicals 39, 61-70. PMID: 20947616

2. Fiorentini, F. et al. (2016) ACS chemical biology 11, 1039-48. PMID: 26771671

3. Fiorentini, F. et al. (2017) ACS chemical biology 12, 2379-2387. PMID: 28783300

4. Overby, LH. et al. (1995) Archives of biochemistry and biophysics 317, 275-84. PMID: 7872795

Note

For research use only

Images

References

Datasheet

Anti-Human FMO5 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human FMO5 Polyclonal Antibody (HD536014)

Overview

Images

References

Datasheet

SDS

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