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Anti-Human FOLR1/FBP Antibody (MOv19), PE (HB825327)

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Anti-Human FOLR1/FBP Antibody (MOv19), PE

Anti-Human FOLR1/FBP Antibody (MOv19), PE

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Datasheet

Overview

Catalog No.	HB825327
Description	Anti-Human FOLR1/FBP Antibody (MOv19), PE [MOv19] (HB825327) is a mouse monoclonal antibody detecting FOLR1 in ELISA, FCM, WB. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	ELISA, FCM, WB
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	MOv19
Conjugation	PE
Clonality	Monoclonal
Target	Folate receptor alpha, FOLR, FOLR1, Adult folate-binding protein, Folate receptor 1, FR-alpha, KB cells FBP, FBP, Ovarian tumor-associated antigen MOv18, Folate receptor, adult
Endotoxin level	Please contact with the lab for this information.
Accession	P15328
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Folate receptor alpha (FOLR1) is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. FOLR1 is the therapeutic target of mirvetuximab soravtansine (Elahere). 1. Zhao, R. et al. (2009) The Journal of biological chemistry 284, 4267-74. PMID: 19074442 2. Chen, C. et al. (2013) Nature 500, 486-9. PMID: 23851396 3. Wibowo, AS. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 15180-8. PMID: 23934049 4. Lacey, SW. et al. (1989) The Journal of clinical investigation 84, 715-20. PMID: 2527252 5. Orr, RB. et al. (1994) Cancer research 54, 3905-11. PMID: 8033114 6. Rijnboutt, S. et al. (1996) The Journal of cell biology 132, 35-47. PMID: 8567728
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Images

Flow CytoMetry

Flow-cytometry using PE anti-human FOLR1 antibody. Hela cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human FOLR1 monoclonal antibody (Catalog: HB825327, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.

References

Datasheet

Anti-Human FOLR1/FBP Antibody (MOv19), PE.pdf

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Anti-Human FOLR1/FBP Antibody (MOv19), PE