Anti-Human FOLR1 Recombinant Nanobody (SAA2048) (HB825013)

Name: Anti-Human FOLR1 Recombinant Nanobody (SAA2048)
Brand: abinScience
SKU: HB825013
Price: 126 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

20ug
50ug
100ug
1mg

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HB825013

Description

Anti-Human FOLR1 Nanobody (SAA2048) [SAA2048] (HB825013) is a alpaca monoclonal antibody detecting FOLR1 in ELISA, FCM. Suitable for Human and Cynomolgus.

Highlights

●Flow Cytometry — Validated for flow cytometry applications.

Species reactivity

Human, Cynomolgus

Applications

ELISA, FCM

Host species

Alpaca

Isotype

VHH-8His-Cys-tag

Clone ID

SAA2048

Clonality

Monoclonal

Target

Folate receptor alpha, FOLR, FOLR1, Adult folate-binding protein, Folate receptor 1, FR-alpha, KB cells FBP, FBP, Ovarian tumor-associated antigen MOv18, Folate receptor, adult

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

P15328

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Folate receptor alpha (FOLR1) is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. FOLR1 is the therapeutic target of mirvetuximab soravtansine (Elahere).

1. Zhao, R. et al. (2009) The Journal of biological chemistry 284, 4267-74. PMID: 19074442

2. Chen, C. et al. (2013) Nature 500, 486-9. PMID: 23851396

3. Wibowo, AS. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 15180-8. PMID: 23934049

4. Lacey, SW. et al. (1989) The Journal of clinical investigation 84, 715-20. PMID: 2527252

5. Orr, RB. et al. (1994) Cancer research 54, 3905-11. PMID: 8033114

6. Rijnboutt, S. et al. (1996) The Journal of cell biology 132, 35-47. PMID: 8567728

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human FOLR1 Nanobody (SAA2048)
Bioactivity

Detects recombinant FOLR1 (Catalog No: HB825011) in indirect ELISA.

References

Datasheet

Anti-Human FOLR1 Recombinant Nanobody (SAA2048).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human FOLR1 Recombinant Nanobody (SAA2048) (HB825013)

Overview

Images

References

Datasheet

SDS

Quick access

Contact Us