Anti-Human FOXP3 Recombinant Antibody (SAA1798) (HV388013)

Name: Anti-Human FOXP3 Recombinant Antibody (SAA1798)
Brand: abinScience
SKU: HV388013
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HV388013

Species reactivity

Human

Applications

ELISA, FCM, WB

Host species

Mouse

Isotype

IgG1, kappa

Clone ID

SAA1798

Clonality

Monoclonal

Target

Forkhead box protein P3, IPEX, Scurfin, FOXP3

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9BZS1

RRID

Anti-Human FOXP3 Antibody (SAA1798) (abinScience Cat# HV388013, RRID:AB_3727560)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Forkhead box protein P3 (FOXP3) is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2.

1. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532

2. Bandukwala, HS. et al. (2011) Immunity 34, 479-91. PMID: 21458306

3. Vent-Schmidt, J. et al. (2014) International reviews of immunology 33, 110-28. PMID: 23947341

4. Passerini, L. et al. (2014) International reviews of immunology 33, 129-45. PMID: 24354325

5. Ramsdell, F. et al. (2014) Nature reviews. Immunology 14, 343-9. PMID: 24722479

6. Xiao, Y. et al. (2014) Cell reports 7, 1471-1480. PMID: 24835996

7. Becher, J. et al. (2018) Developmental cell 47, 592-607.e6. PMID: 30513302

8. Yang, J. et al. (2020) EMBO reports 21, e50308. PMID: 32644293

9. McMurchy, AN. et al. (2013) Blood 121, 1265-75. PMID: 23169781

10. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human FOXP3 Antibody (SAA1798)

References

Datasheet

Anti-Human FOXP3 Recombinant Antibody (SAA1798).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human FOXP3 Recombinant Antibody (SAA1798) (HV388013)

Overview

Images

References

Datasheet

SDS

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