Anti-Human FYN Polyclonal Antibody (HC984014)

Name: Anti-Human FYN Polyclonal Antibody
Brand: abinScience
SKU: HC984014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HC984014

Description

Anti-Human FYN Polyclonal Antibody (HC984014) is a rabbit polyclonal antibody detecting FYN. Suitable for Human, Mouse, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human FYN (Thr85-Leu537).

Target

EC:2.7.10.2, FYN, Proto-oncogene Syn, Proto-oncogene c-Fyn, SLK, Src-like kinase, Tyrosine-protein kinase Fyn, p59-Fyn

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P06241

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Tyrosine-protein kinase Fyn is a ~60 kDa protein. Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT.

1. Wolf, RM. et al. (2001) Journal of neurobiology 49, 62-78. PMID: 11536198

2. Palacios, EH. et al. (2004) Oncogene 23, 7990-8000. PMID: 15489916

3. Meriane, M. et al. (2004) The Journal of cell biology 167, 687-98. PMID: 15557120

4. Yang, C. et al. (2006) Molecular cell 21, 135-41. PMID: 16387660

5. Goh, YM. et al. (2010) The Journal of biological chemistry 285, 10122-10129. PMID: 20100835

6. Raab, M. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 8891-5. PMID: 7568038

7. Rigley, K. et al. (1995) Journal of immunology (Baltimore, Md. : 1950) 154, 1136-45. PMID: 7822789

8. Castaño, J. et al. (2007) Molecular and cellular biology 27, 1745-57. PMID: 17194753

Note

For research use only

Images

Western blot

Western blot analysis was performed using anti-FYN polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse brain lysate
Lane 2: Rat brain lysate

References

Datasheet

Anti-Human FYN Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human FYN Polyclonal Antibody (HC984014)

Overview

Images

References

Datasheet

SDS

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