Anti-Human GABARAPL1 Polyclonal Antibody (HP284014)

Name: Anti-Human GABARAPL1 Polyclonal Antibody
Brand: abinScience
SKU: HP284014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HP284014

Description

Anti-Human GABARAPL1 Polyclonal Antibody (HP284014) is a rabbit polyclonal antibody detecting GABARAPL1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Cavia porcellus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human GABARAPL1 (Met1-Lys117).

Target

Early estrogen-regulated protein, Gamma-aminobutyric acid receptor-associated protein-like 1, GEC-1, GABARAPL1, Glandular epithelial cell protein 1, GEC1, GABA(A) receptor-associated protein-like 1

Purification

Purified by antigen affinity column.

Accession

Q9H0R8

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) is a ~14 kDa protein. Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.

1. Chen, C. et al. (2006) The Journal of biological chemistry 281, 7983-93. PMID: 16431922

2. Chakrama, FZ. et al. (2010) Autophagy 6, 495-505. PMID: 20404487

3. An, H. et al. (2019) Molecular cell 74, 891-908.e10. PMID: 31006537

4. Chino, H. et al. (2019) Molecular cell 74, 909-921.e6. PMID: 31006538

Note

For research use only.

Images

References

Datasheet

Anti-Human GABARAPL1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Human GABARAPL1 Polyclonal Antibody (HP284014)

Overview

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References

Datasheet

SDS

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