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Anti-Human GABBR2 Polyclonal Antibody (HF750014)

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Overview
Catalog No.HF750014
Description
Anti-Human GABBR2 Polyclonal Antibody (HF750014) is a rabbit polyclonal antibody detecting GABBR2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human GABBR2 (Ser57-Lys467).
Target Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, HG20, GABBR2, GPR51, GPRC3B
Purification Purified by antigen affinity column.
Accession O75899
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2) is a ~105 kDa protein. Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission.

1. Villemure, JF. et al. (2005) The Biochemical journal 388, 47-55. PMID: 15617512
2. Nomura, R. et al. (2008) The Journal of biological chemistry 283, 4665-73. PMID: 18165688
3. Geng, Y. et al. (2012) Nature neuroscience 15, 970-8. PMID: 22660477
4. Geng, Y. et al. (2013) Nature 504, 254-9. PMID: 24305054
5. White, JH. et al. (1998) Nature 396, 679-82. PMID: 9872316
6. Kuner, R. et al. (1999) Science (New York, N.Y.) 283, 74-7. PMID: 9872744
7. Ng, GY. et al. (1999) The Journal of biological chemistry 274, 7607-10. PMID: 10075644
8. Sullivan, R. et al. (2000) The Journal of pharmacology and experimental therapeutics 293, 460-7. PMID: 10773016
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human GABBR2 Polyclonal Antibody

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