Anti-Human GCGR Recombinant Antibody (SAA0132), FITC (HW547117)

Name: Anti-Human GCGR Recombinant Antibody (SAA0132), FITC
Brand: abinScience
SKU: HW547117
Price: 223 USD
Availability: InStock

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Overview

Catalog No.	HW547117
Species reactivity	Human
Applications	FCM
Host species	Human
Isotype	IgG2, kappa
Clone ID	SAA0132
Conjugation	FITC
Clonality	Monoclonal
Target	GCGR, Glucagon receptor, GL-R
Endotoxin level	Please contact with the lab for this information.
Associated products	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10), FITC
Accession	P47871
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Glucagon receptor (GCGR) is a ~54 kDa protein. G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. 1. Qiao, A. et al. (2020) Science (New York, N.Y.) 367, 1346-1352. PMID: 32193322 2. Cong, Z. et al. (2024) Cell discovery 10, 18. PMID: 38346960
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.