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Anti-Human Glucagon R/GCGR Polyclonal Antibody (HW547014)

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Overview
Catalog No.HW547014
Description
Anti-Human GCGR Polyclonal Antibody (HW547014) is a rabbit polyclonal antibody detecting GCGR. Suitable for Mouse, Rat, and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human GCGR (Ala26-Lys136).
Target GCGR, GL-R, Glucagon receptor
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P47871
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Glucagon receptor (GCGR) is a ~54 kDa protein. G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase.

1. Qiao, A. et al. (2020) Science (New York, N.Y.) 367, 1346-1352. PMID: 32193322
2. Cong, Z. et al. (2024) Cell discovery 10, 18. PMID: 38346960
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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Volume
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human Glucagon R/GCGR Polyclonal Antibody

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