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Anti-Human GFM2 Polyclonal Antibody (HD643014)

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Overview
Catalog No.HD643014
Description
Anti-Human GFM2 Polyclonal Antibody (HD643014) is a rabbit polyclonal antibody detecting GFM2. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human GFM2 (Ala461-Thr779).
Target EC:3.6.5.-, EF-G2mt, EFG2, Elongation factor G 2, mitochondrial, Elongation factor G2, GFM2, RRF2mt, Ribosome-releasing factor 2, mitochondrial, hEFG2, mEF-G 2
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q969S9
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Ribosome-releasing factor 2, mitochondrial (GFM2) is a ~86 kDa protein. Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.

1. Tsuboi, M. et al. (2009) Molecular cell 35, 502-10. PMID: 19716793
2. Kummer, E. et al. (2021) Molecular cell 81, 2566-2582.e6. PMID: 33878294
Note For research use only
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Formula
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Anti-Human GFM2 Polyclonal Antibody

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