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Anti-Human GNG2 Polyclonal Antibody (HX006014)

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Overview
Catalog No.HX006014
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human GNG2 (Ala2-Leu71).
Target GNG2, G gamma-I, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Purification Purified by antigen affinity column.
Accession P59768
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (GNG2) is a ~7 kDa protein. Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

1. García-Nafría, J. et al. (2018) Nature 558, 620-623. PMID: 29925951
2. Xu, P. et al. (2021) Nature 592, 469-473. PMID: 33762731
3. Huang, S. et al. (2021) Cell research 31, 1036-1038. PMID: 34239069
4. Tan, Y. et al. (2022) Cell discovery 8, 50. PMID: 35610220
5. Huang, S. et al. (2022) Molecular cell 82, 2681-2695.e6. PMID: 35714614
6. Zhang, S. et al. (2022) Nature structural & molecular biology 29, 677-687. PMID: 35835867
7. Cao, C. et al. (2022) Neuron 110, 3154-3167.e7. PMID: 36087581
8. He, L. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2209917120. PMID: 36989299
9. Pei, Y. et al. (2023) Biochemical and biophysical research communications 671, 327-334. PMID: 37327704
10. Xu, Z. et al. (2023) Nature 624, 672-681. PMID: 37935376
Note For research use only.
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