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Anti-Human GRB10 Polyclonal Antibody (HC527014)

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Overview
Catalog No.HC527014
Description
Anti-Human GRB10 Polyclonal Antibody (HC527014) is a rabbit polyclonal antibody detecting GRB10. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human GRB10 (Lys167-Leu417).
Target GRB10, GRB10 adapter protein, GRBIR, Growth factor receptor-bound protein 10, Insulin receptor-binding protein Grb-IR, KIAA0207
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q13322
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Growth factor receptor-bound protein 10 (GRB10) is a ~67 kDa protein. Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation.

Note For research use only
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Anti-Human GRB10 Polyclonal Antibody

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