Anti-Human GSDMB Polyclonal Antibody (HP757014)

Name: Anti-Human GSDMB Polyclonal Antibody
Brand: abinScience
SKU: HP757014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HP757014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human GSDMB (Pro200-Ser411).

Target

GSDML, p16, GSDMB-NT, GSDMB-CT, Gasdermin-like protein, GSDMB, p30, Gasdermin-B

Purification

Purified by antigen affinity column.

Accession

Q8TAX9

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Gasdermin-B (GSDMB) is a ~47 kDa protein. Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-B, N-terminal) binds to membranes and forms pores, triggering pyroptosis. Also acts as a regulator of epithelial cell repair independently of programmed cell death: translocates to the plasma membrane and promotes epithelial maintenance and repair by regulating PTK2/FAK-mediated phosphorylation of PDGFA.

1. Zhou, Z. et al. (2020) Science (New York, N.Y.) 368. PMID: 32299851

2. Rana, N. et al. (2022) Cell 185, 283-298.e17. PMID: 35021065

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human GSDMB polyclonal antibody at 1ug/mL on recombinant Human GSDMB (Catalog No. HP757012).

References

Datasheet

Anti-Human GSDMB Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human GSDMB Polyclonal Antibody (HP757014)

Overview

Images

References

Datasheet

SDS

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