Anti-Human GZMB Recombinant Antibody (Fv02) (HY574107)

Name: Anti-Human GZMB Recombinant Antibody (Fv02)
Brand: abinScience
SKU: HY574107
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HY574107
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1
Clone ID	Fv02
Clonality	Monoclonal
Target	Cathepsin G-like 1, Granzyme-2, GZMB, grzmB, Fragmentin-2, Human lymphocyte protein, HLP, CTLA-1, CGL1, CTSGL1, CSPB, Lymphocyte protease, T-cell serine protease 1-3E, Granzyme B, Granzyme-B, CTLA1, GRB, C11, Cytotoxic T-lymphocyte proteinase 2, SECT
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P10144
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Granzyme B (GZMB) is a ~27 kDa protein. Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis. 1. Poe, M. et al. (1991) The Journal of biological chemistry 266, 98-103. PMID: 1985927 2. Hameed, A. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 141, 3142-7. PMID: 3262682 3. Krähenbühl, O. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 141, 3471-7. PMID: 3263427 4. Froelich, CJ. et al. (1993) Journal of immunology (Baltimore, Md. : 1950) 151, 7161-71. PMID: 8258716 5. Liu, Y. et al. (2020) Science immunology 5. PMID: 31953257 6. Zhang, Z. et al. (2020) Nature 579, 415-420. PMID: 32188940 7. Yang, X. et al. (1998) The Journal of biological chemistry 273, 34278-83. PMID: 9852092
Note	For research use only.