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Anti-Human HCAR2 Polyclonal Antibody (HD417014)

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Overview
Catalog No.HD417014
Description
Anti-Human HCAR2 Polyclonal Antibody (HD417014) is a rabbit polyclonal antibody detecting HCAR2. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human HCAR2 (Asn2-Val33&Tyr295-Pro363).
Target G-protein coupled receptor 109A, G-protein coupled receptor HM74A, GPR109A, HCA2, HCAR2, HM74A, Hydroxycarboxylic acid receptor 2, NIACR1, Niacin receptor 1, Nicotinic acid receptor
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q8TDS4
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Hydroxycarboxylic acid receptor 2 (HCAR2) is a ~41 kDa protein. Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.

Note For research use only
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Formula
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Anti-Human HCAR2 Polyclonal Antibody

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