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Anti-Human HECTD1 Polyclonal Antibody (HP247014)

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Overview
Catalog No.HP247014
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human HECTD1 (Lys659-Thr801).
Target HECT-type E3 ubiquitin transferase HECTD1, E3 ubiquitin-protein ligase HECTD1, HECTD1, KIAA1131, EULIR, HECT domain-containing protein 1, E3 ligase for inhibin receptor
Purification Purified by antigen affinity column.
Accession Q9ULT8
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

E3 ubiquitin-protein ligase HECTD1 is a ~289 kDa protein. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure. Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal.

1. Lv, K. et al. (2021) Cell stem cell 28, 1275-1290.e9. PMID: 33711283
Note For research use only.
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Anti-Human HECTD1 Polyclonal Antibody

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