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Anti-Human HELLS Polyclonal Antibody (HV401014)

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Overview
Catalog No.HV401014
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human HELLS (Asp523-His748).
Target PASG, Lymphoid-specific helicase, SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6, SMARCA6, HELLS, Proliferation-associated SNF2-like protein
Purification Purified by antigen affinity column.
Accession Q9NRZ9
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Lymphoid-specific helicase (HELLS) is a ~97 kDa protein. ATP-dependent chromatin remodeler that regulates chromatin accessibility, DNA methylation, and histone modifications. It facilitates de novo DNA methylation at repetitive sequences and promotes transcriptional silencing via recruitment of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), contributing to heterochromatin formation and repression of transposable elements. Also involved in DNA repair by recruiting DNA damage response mediators to double-strand breaks in heterochromatin, promoting homologous recombination via RBBP8/CtIP-dependent end resection. During meiosis, it is recruited by PRDM9 to recombination hotspots, aiding chromatin opening. Through these diverse roles, is crucial for processes such as development, differentiation, and genomic stability.

1. Unoki, M. et al. (2019) The Journal of clinical investigation 129, 78-92. PMID: 30307408
2. Burrage, J. et al. (2012) Journal of cell science 125, 5524-34. PMID: 22946062
3. Kollárovič, G. et al. (2020) Nucleic acids research 48, 1872-1885. PMID: 31802118
4. Spruce, C. et al. (2020) Genes & development 34, 398-412. PMID: 32001511
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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V₁ (Stock Vol.)
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Anti-Human HELLS Polyclonal Antibody

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