Anti-Human HSP90AB1 Polyclonal Antibody (HY418014)

Name: Anti-Human HSP90AB1 Polyclonal Antibody
Brand: abinScience
SKU: HY418014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HY418014

Description

Anti-Human HSP90AB1 Polyclonal Antibody (HY418014) is a rabbit polyclonal antibody detecting HSP90AB1. Suitable for Mouse, Human, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human HSP90AB1 (Met1-Asp724).

Target

HSP 84, HSP 90, HSP84, HSP90AB1, HSP90B, HSPC2, HSPC3, HSPCB, Heat shock 84 kDa, Heat shock protein HSP 90-beta, Heat shock protein family C member 3

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P08238

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Heat shock protein HSP 90-beta (HSP90AB1) is a ~83 kDa protein. Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself.

1. Chadli, A. et al. (2006) Molecular and cellular biology 26, 1722-30. PMID: 16478993

2. Retzlaff, M. et al. (2009) EMBO reports 10, 1147-53. PMID: 19696785

3. Pearl, LH. (2016) Biopolymers 105, 594-607. PMID: 26991466

4. Verma, S. et al. (2016) Biochimie 127, 227-40. PMID: 27295069

5. Khurana, N. et al. (2015) Frontiers in oncology 5, 100. PMID: 25973397

6. Shang, Y. et al. (2014) Biochemical and biophysical research communications 446, 387-92. PMID: 24613385

7. Didelot, C. et al. (2008) Cell death and differentiation 15, 859-66. PMID: 18239673

8. Cheng, MB. et al. (2010) Cellular signalling 22, 1206-13. PMID: 20353823

9. Zhang, M. et al. (2020) Cell 181, 637-652.e15. PMID: 32272059

Note

For research use only

Images

References

Datasheet

Anti-Human HSP90AB1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human HSP90AB1 Polyclonal Antibody (HY418014)

Overview

Images

References

Datasheet

SDS

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