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Anti-Human HTR2C Polyclonal Antibody (HB733014)

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Overview
Catalog No.HB733014
Description
Anti-Human HTR2C Polyclonal Antibody (HB733014) is a rabbit polyclonal antibody detecting 5-HTR2C in ELISA, IHC, WB. Suitable for Human and Dog.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human HTR2C (Leu236-Lys311).
Target 5-hydroxytryptamine receptor 2C, 5-HT-2C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine receptor 1C, 5-HT-1C, 5-HT1C, Serotonin receptor 2C, HTR2C, HTR1C
Purification Purified by antigen affinity column.
Accession P28335
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

5-hydroxytryptamine receptor 2C (HTR2C) is a ~51 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR2C is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.

1. Schaerlinger, B. et al. (2003) British journal of pharmacology 140, 277-84. PMID: 12970106
2. Cussac, D. et al. (2008) European journal of pharmacology 594, 32-8. PMID: 18703043
3. Knauer, CS. et al. (2009) Naunyn-Schmiedeberg's archives of pharmacology 379, 461-71. PMID: 19057895
4. Peng, Y. et al. (2018) Cell 172, 719-730.e14. PMID: 29398112
5. Stam, NJ. et al. (1994) European journal of pharmacology 269, 339-48. PMID: 7895773
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human HTR2C Polyclonal Antibody

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