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Anti-Human HTR6 Polyclonal Antibody (HA663014)

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Overview
Catalog No.HA663014
Description
Anti-Human HTR6 Polyclonal Antibody (HA663014) is a rabbit polyclonal antibody detecting 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6; HTR6 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant human HTR6 (Pro321-Asn440).
Target 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6; HTR6
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P50406
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

5-hydroxytryptamine receptor 6 (HTR6) is a ~46 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also has a high affinity for tricyclic psychotropic drugs. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity.

1. Huang, S. et al. (2022) Molecular cell 82, 2681-2695.e6. PMID: 35714614
2. He, L. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2209917120. PMID: 36989299
3. Pei, Y. et al. (2023) Biochemical and biophysical research communications 671, 327-334. PMID: 37327704
4. Kohen, R. et al. (1996) Journal of neurochemistry 66, 47-56. PMID: 8522988
5. Meffre, J. et al. (2012) EMBO molecular medicine 4, 1043-56. PMID: 23027611
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human HTR6 Polyclonal Antibody

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