Anti-Human Human CYP19A1 Recombinant Antibody (SAA2693) (HY384013)

Name: Anti-Human Human CYP19A1 Recombinant Antibody (SAA2693)
Brand: abinScience
SKU: HY384013
Price: 191 USD
Availability: InStock

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100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HY384013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA2693

Clonality

Monoclonal

Target

ARO1, Aromatase, CYAR, CYP19, CYP19A1, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, EC:1.14.14.14, Estrogen synthase

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P11511

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Aromatase (CYP19A1) is a ~57 kDa protein. A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone.

1. Baravalle, R. et al. (2017) The Journal of steroid biochemistry and molecular biology 167, 23-32. PMID: 27702664

2. Corbin, CJ. et al. (1988) Proceedings of the National Academy of Sciences of the United States of America 85, 8948-52. PMID: 2848247

3. Sohl, CD. et al. (2010) The Journal of biological chemistry 285, 17734-43. PMID: 20385561

4. Cheng, Q. et al. (2012) The Journal of biological chemistry 287, 29554-67. PMID: 22773874

Note

For research use only

Images

References

Datasheet

Anti-Human Human CYP19A1 Recombinant Antibody (SAA2693).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human Human CYP19A1 Recombinant Antibody (SAA2693) (HY384013)

Overview

Images

References

Datasheet

SDS

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