Anti-Human IFIT1 Polyclonal Antibody (HY426014)

Name: Anti-Human IFIT1 Polyclonal Antibody
Brand: abinScience
SKU: HY426014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HY426014

Description

Anti-Human IFIT1 Polyclonal Antibody (HY426014) is a rabbit polyclonal antibody detecting IFIT1 in ELISA, IHC, WB. Suitable for Human and Macaca fascicularis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human IFIT1 (Met1-Pro478).

Target

IFI-56K, G10P1, Interferon-induced protein with tetratricopeptide repeats 1, IFIT-1, IFNAI1, IFIT1, ISG56, IFI56, Interferon-induced 56 kDa protein, P56

Purification

Purified by antigen affinity column.

Accession

P09914

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Antiviral innate immune response effector IFIT1 is a ~55 kDa protein. Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E. Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro. Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families.

1. Pichlmair, A. et al. (2011) Nature immunology 12, 624-30. PMID: 21642987

2. Daugherty, MD. et al. (2016) eLife 5. PMID: 27240734

3. Geng, J. et al. (2024) RNA (New York, N.Y.) 30, 1292-1305. PMID: 39009378

4. Abbas, YM. et al. (2013) Nature 494, 60-4. PMID: 23334420

5. Abbas, YM. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2106-E2115. PMID: 28251928

6. Russ, A. et al. (2022) EMBO reports 23, e55648. PMID: 36285486

7. Terenzi, F. et al. (2008) The EMBO journal 27, 3311-21. PMID: 19008854

8. Raychoudhuri, A. et al. (2011) Journal of virology 85, 12881-9. PMID: 21976647

Note

For research use only.

Images

References

Datasheet

Anti-Human IFIT1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human IFIT1 Polyclonal Antibody (HY426014)

Overview

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References

Datasheet

SDS

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