Anti-Human IFIT5 Polyclonal Antibody (HC576014)

Name: Anti-Human IFIT5 Polyclonal Antibody
Brand: abinScience
SKU: HC576014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HC576014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human IFIT5 (Met1-Ile482).

Target

ISG58, RI58, IFIT-5, P58, Interferon-induced protein with tetratricopeptide repeats 5, IFIT5, Retinoic acid- and interferon-inducible 58 kDa protein, Interferon-induced 58 kDa protein

Purification

Purified by antigen affinity column.

Accession

Q13325

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interferon-induced protein with tetratricopeptide repeats 5 (IFIT5) is a ~55 kDa protein. Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments. Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection.

1. Katibah, GE. et al. (2013) Molecular cell 49, 743-50. PMID: 23317505

2. Feng, F. et al. (2013) Cell research 23, 1055-8. PMID: 23774268

3. Katibah, GE. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 12025-30. PMID: 25092312

4. Abbas, YM. et al. (2013) Nature 494, 60-4. PMID: 23334420

5. Zheng, C. et al. (2015) Cellular signalling 27, 2343-54. PMID: 26334375

Note

For research use only.

Images

References

Datasheet

Anti-Human IFIT5 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human IFIT5 Polyclonal Antibody (HC576014)

Overview

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References

Datasheet

SDS

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