Anti-Human IGF2BP1 Polyclonal Antibody (HP412014)

Name: Anti-Human IGF2BP1 Polyclonal Antibody
Brand: abinScience
SKU: HP412014
Price: 96 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HP412014

Description

Anti-Human IGF2BP1 Polyclonal Antibody (HP412014) is a rabbit polyclonal antibody detecting IGF2BP1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Danio rerio, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human IGF2BP1 (Val194-Asn369).

Target

VICKZ family member 1, Zipcode-binding protein 1, IGF2BP1, VICKZ1, Coding region determinant-binding protein, IMP1, IMP-1, ZBP1, IGF-II mRNA-binding protein 1, CRDBP, Insulin-like growth factor 2 mRNA-binding protein 1, ZBP-1, CRD-BP, IGF2 mRNA-binding protein 1

Purification

Purified by antigen affinity column.

Accession

Q9NZI8

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is a ~63 kDa protein. RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons.

1. Huang, H. et al. (2018) Nature cell biology 20, 285-295. PMID: 29476152

2. Zhu, S. et al. (2020) Nature communications 11, 1685. PMID: 32245947

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-IGF2BP1 polyclonal antibody at 1μg/ml on various samples.
Lane 1: K562 cell lysate
Lane 2: 293T cell lysate

References

Datasheet

Anti-Human IGF2BP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human IGF2BP1 Polyclonal Antibody (HP412014)

Overview

Images

References

Datasheet

SDS

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