Anti-Human IKBKG Polyclonal Antibody (HA521014)

Name: Anti-Human IKBKG Polyclonal Antibody
Brand: abinScience
SKU: HA521014
Price: 96 USD
Availability: InStock

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SDS

Overview

Catalog No.

HA521014

Description

Anti-Human IKBKG Polyclonal Antibody (HA521014) is a rabbit polyclonal antibody detecting IKBKG in ELISA, IHC, WB. Suitable for Rattus norvegicus, Mus musculus, Sus scrofa, and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human IKBKG (Met1-Glu223).

Target

IKBKG

Purification

Purified by antigen affinity column.

Accession

Q9Y6K9

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

NF-kappa-B essential modulator, NEMO, FIP-3, IkB kinase-associated protein 1, IKKAP1, Inhibitor of nuclear factor kappa-B kinase subunit gamma, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma, NF-kappa-B essential modifier, IKBKG, FIP3, NEMO

Background

NF-kappa-B essential modulator (IKBKG) is a ~48 kDa protein. Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3.

1. Zhou, H. et al. (2004) Nature 427, 167-71. PMID: 14695475

2. Arimoto, K. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 15856-61. PMID: 20724660

3. Zotti, T. et al. (2011) The Journal of biological chemistry 286, 22924-33. PMID: 21518757

4. Rothwarf, DM. et al. (1998) Nature 395, 297-300. PMID: 9751060

5. Wu, CJ. et al. (2006) Nature cell biology 8, 398-406. PMID: 16547522

6. Wu, CJ. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 3023-8. PMID: 18287044

7. Cordier, F. et al. (2009) The Journal of biological chemistry 284, 2902-2907. PMID: 19033441

8. Lo, YC. et al. (2009) Molecular cell 33, 602-15. PMID: 19185524

9. Nanda, SK. et al. (2011) The Journal of experimental medicine 208, 1215-28. PMID: 21606507

10. Yang, YK. et al. (2016) The Journal of biological chemistry 291, 25921-25936. PMID: 27777308

Note

For research use only.

Images

References

Datasheet

Anti-Human IKBKG Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human IKBKG Polyclonal Antibody (HA521014)

Overview

Images

References

Datasheet

SDS

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