Anti-Human IL1RL1/ST2 Polyclonal Antibody (HX139024)

Name: Anti-Human IL1RL1/ST2 Polyclonal Antibody
Brand: abinScience
SKU: HX139024
Price: 168 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HX139024

Description

Anti-Human IL1RL1/ST2 Polyclonal Antibody (HX139024) is a rabbit polyclonal antibody detecting Protein ST2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human IL1RL1/ST2 (Lys19-Pro323).

Target

T1, DER4, Interleukin-1 receptor-like 1, ST2, IL1RL1, Protein ST2

Purification

Purified by antigen affinity column.

Accession

Q01638

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-1 receptor-like 1 (IL1RL1/ST2) is a ~63 kDa protein. Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.

1. Yi, XM. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2116279119. PMID: 35238669

2. Schmitz, J. et al. (2005) Immunity 23, 479-90. PMID: 16286016

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human IL1RL1/ST2 polyclonal antibody at 1ug/mL on recombinant Human IL1RL1/ST2 (Catalog No. HX139022).

References

Datasheet