Anti-Human IL-33 Recombinant Antibody (C2_2E12) (HF543013)

Name: Anti-Human IL-33 Recombinant Antibody (C2_2E12)
Brand: abinScience
SKU: HF543013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HF543013

Species reactivity

Human

Applications

Blocking, ELISA, WB

Host species

Mouse

Isotype

IgG1

Clone ID

C2_2E12

Clonality

Monoclonal

Target

NF-HEV, IL-1F11, C9orf26, IL-33, Interleukin-1 family member 11, IL33, Nuclear factor from high endothelial venules, NFHEV, Interleukin-33, IL1F11

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O95760

RRID

Anti-Human IL33 Antibody (C2_2E12) (abinScience Cat# HF543013, RRID:AB_3725209)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Interleukin-33 (IL33) is a ~30 kDa protein. Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as an enhancer of polarization of alternatively activated macrophages. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury.

1. Schmitz, J. et al. (2005) Immunity 23, 479-90. PMID: 16286016

2. Kurowska-Stolarska, M. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 6469-77. PMID: 19841166

3. Komai-Koma, M. et al. (2007) European journal of immunology 37, 2779-86. PMID: 17853410

4. Moussion, C. et al. (2008) PloS one 3, e3331. PMID: 18836528

Note

For research use only.

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