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Anti-Human IPO11 Polyclonal Antibody (HD693014)

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Overview
Catalog No.HD693014
Description
Anti-Human IPO11 Polyclonal Antibody (HD693014) is a rabbit polyclonal antibody detecting IPO11. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human IPO11 (Met1-His284).
Target IPO11, Imp11, Importin-11, RANBP11, Ran-binding protein 11, RanBP11
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9UI26
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Importin-11 (IPO11) is a ~112 kDa protein. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Note For research use only
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Formula
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Anti-Human IPO11 Polyclonal Antibody

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