Anti-Human IRGQ Polyclonal Antibody (HD628014)

Name: Anti-Human IRGQ Polyclonal Antibody
Brand: abinScience
SKU: HD628014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
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Overview

Catalog No.

HD628014

Description

Anti-Human IRGQ Polyclonal Antibody (HD628014) is a rabbit polyclonal antibody detecting IRGQ. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human IRGQ (Met1-Thr331).

Target

IRGQ, IRGQ1, Immunity-related GTPase family Q protein

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q8WZA9

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Immunity-related GTPase family Q protein (IRGQ) is a ~62 kDa protein. Autophagy receptor that specifically promotes clearance of misfolded MHC class I molecules by targeting them to the lysosome for degradation. Acts as a molecular adapter that specifically recognizes and binds (1) misfolded MHC class I molecules following their ubiquitination, as well as (2) autophagy-related proteins, promoting the recruitment of misfolded MHC class I molecules to autophagy machinery for degradation. Degradation of misfolded MHC class I molecules is essential to prevent accumulation of defective MHC class I complexes at the surface of CD8(+) T-cells and prevent a stronger T-cell-mediated response. In contrast to other members of the family, does not show GTPase activity.

1. Herhaus, L. et al. (2024) Cell 187, 7285-7302.e29. PMID: 39481378

Note

For research use only

Images

References

Datasheet

Anti-Human IRGQ Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human IRGQ Polyclonal Antibody (HD628014)

Overview

Images

References

Datasheet

SDS

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