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Anti-Human IST1 Polyclonal Antibody (HX152014)

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Overview
Catalog No.HX152014
Description
Anti-Human IST1 Polyclonal Antibody (HX152014) is a rabbit polyclonal antibody detecting IST1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human IST1 (Met1-Glu186).
Target Putative MAPK-activating protein PM28, IST1, IST1 homolog, KIAA0174, hIST1
Purification Purified by antigen affinity column.
Accession P53990
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

IST1 homolog is a ~39 kDa protein. ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2.

1. Bajorek, M. et al. (2009) Molecular biology of the cell 20, 1360-73. PMID: 19129479
2. Vietri, M. et al. (2015) Nature 522, 231-5. PMID: 26040712
3. Gu, M. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2166-E2175. PMID: 28242692
4. Agromayor, M. et al. (2009) Molecular biology of the cell 20, 1374-87. PMID: 19129480
5. Allison, R. et al. (2013) The Journal of cell biology 202, 527-43. PMID: 23897888
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human IST1 Polyclonal Antibody

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